PGC Basal Insulin

Development Stage

Pre-Clinical

Description

Insulin is a 5.8 kDa small protein hormone responsible for cellular glucose uptake. For type 1 diabetics, daily insulin is required for survival. PGC Insulin is a 1/day native basal insulin. Due to its Zn binding properties, Insulin binds well to the PGC-Metal Bridge carrier.

Status

PGC Insulin (10% loading by weight) has been injected subcutaneously into 6 STZ-diabetic Sprague Dawley rats at a dose of 1 mg/kg. Lantus® (Insulin-glargine, Sanofi-Aventis) was dosed at 1 mg/mL as a control. These experiments show a favorable comparison to Lantus.